Cannabinoids, Anandamides And Bliss Consciousness

A sequential biochemical and neurological pathway through life

Draft For Review June 22, 2002


Recent advances in Cannabinoid receptor biochemistry have uncovered numerous relationships of the endogenous Anandamides and exogenous Cannabinoids with a whole sequence of neurological and general biochemical processes. Anandamides play an important role from fetal development throughout childhood and are not only protective of the developing nervous system and early immunity, but are keys to the blissful joyous innocence of childhood. While the role of Cannabinoids in conception and implantation remains complicated, it does appear that Cannabis during pregnancy can lead to relatively blissful healthy children.

As animals begin puberty, the Anandamides often fade as the sex hormones kick in. The Anadamides are still protective including modulation of these hormones and other new growth processes. In rats and other herbivores this 1st year maturing coincides with the maturing of Cannabis, and by fall mature Cannabis is available to herbivores and birds. This allows young animals to supplement the dwindling Anandamides and reinforces herbivore grazing, nutrition and growth. In humans, the whole gamut of agricultural activites and the seasons, are a vital part of growth, building strong healthy bodies, active participation with plants and animals, raising happy children, seasonal social events, and a prosperous productive Cannabis Culture, with Cannabis playing a key role not only in Farming but also Ranching, Land Reclamation and a vast array of useful products.

The supplementation with Cannabis in adolescence is well known in herbivores and human teens. It may also be related to other forms of self awareness and chemical stimulation in the environment, such as beer and other active plants, such as caffeine, cocaine, opiates, psychedelics, ginseng and many tasty herbs and sensous fragrances. It's a time of awakening of the senses and mind to the wide variety of available culinary, nutritional, medicinal and spiritual plants worldwide. A teenage approach to having fun.

In young adults, Cannabis begins to play other roles in modulation of agression, stress, inhancement of social, artistic and sexual pleasures. Cannabis use is often associated with relaxed socialization, parties, music, dancing, and courtship. Its light headed springtime carefree feeling balances the many difficulties of these years, although in prohibitionistic societies it can lead to much trouble and disruption of parental and societal expectations and personal goals. Nevertheless, Cannabis is widely enjoyed and highly reguarded by large percentages of young adults.

And then as adults begin to feel the wear and tear of life's hard work and aging begins to show, Cannabis can play important roles in nervous system, cardiovascular, digestive and endocrine protection, leading to a longer more active life, while the kind smoke gives a pleasurable reward after a hard day's work. Whole Cannabis has an extraordinary abundance of high energy nutritients, especially Essential Amino Acids, Essential Fatty Acids, Water Soluble and Fat Soluble Vitamins. The amounts of Fat Soluble Vitamins are exceptionally abundant. This rich healthy combination has a very high synergistic quotient. Numerous types of preparations and extractions have been developed thoughout history, with uses as teas, spices, resins, smokes, tinctures and oils being the most widely used for a whole range of nutritional and medical needs plus a warm feeling of well being. But remember the ancient saying about Hashish, "A little warms, a lot burns!".

In older adults and the elderly, Cannabis can take up some of the slack for the decreasing Anandamides, Hormones and other biochemicals, providing support for numerous systems, as seen in the wide range of recepetor sites. When used in conjunction with the wide array of nutritional and hormonal supplements now available, it can help maintain a fairly complete biochemical equilibrium. But more importantly, Cannabis plays supporting roles in the immune system, perhaps much the same as Anandamides play in early life. Immune modulation, protection and inflamtion responses that can help sustain weakened, injured, infected, and malnurished individuals. With the global catastrophy of war, erosion, malnutrition, starvation, disease, incredible suffering and death, Cannabis has a much larger role and potential benefit for all life.

Then with advanced age related degeneration, disease and pain, Cannabis can play a vital role in easing the physical and mental suffering, leading to a calmer feeling of well being, better rest and sleep, enjoyment of the later days and to a more spiritual approach to our ultimate death and rebirth. Cannabis use among a full range of ages means much fuller family relationships and generational closeness that has been all but destroyed by prohibition.

So as we now see, Anadamides and Cannbinoids play a deep fundamental sequential lifelong role in our development from the gleam of conception, the wonder of pregnancy, childhood joyful bliss, to adolescent excitement and fun, young adult active and sexual lives, mature health and happiness and onto the easing of the pains of old age, our spiritual maturity and the harmony of bliss consciousness, the cyclic continuum life and oneness with the Great Spirit.



21st Century References:


Gruber AJ, Pope HG Jr. 2002 
       Marijuana use among adolescents. 
       Pediatr Clin North Am. 2002 Apr;49(2):389-413. Review. 
       PMID: 11993290 [PubMed - indexed for MEDLINE]

Mechoulam R, Spatz M, Shohami E. 2002 
       Endocannabinoids and neuroprotection.
       Sci STKE. 2002 Apr 23;2002(129):RE5. Review.
       PMID: 11972360 [PubMed - indexed for MEDLINE]

Elphick MR. 2002 
       Evolution of Cannabinoid Receptors in Vertebrates: 
       Identification of a CB(2) Gene in the Puffer Fish Fugu rubripes.
       Biol Bull. 2002 Apr;202(2):104-7. No abstract available.
       PMID: 11971807 [PubMed - in process]

Marsicano G, Moosmann B, Hermann H, Lutz B, Behlt C. 2002 
       Neuroprotective properties of cannabinoids against oxidative stress: 
       role of the cannabinoid receptor CB1.
       J Neurochem. 2002 Feb;80(3):448-56.
       PMID: 11905991 [PubMed - indexed for MEDLINE]

Molina-Holgado F, Molina-Holgado E, Guaza C, Rothwell NJ. 2002 
       Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on
       lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
       J Neurosci Res. 2002 Mar 15;67(6):829-36.
       PMID: 11891798 [PubMed - indexed for MEDLINE]

Wenger T, Gerendai I, Fezza F, Gonzalez S, Bisogno T, Fernandez-Ruiz J, Di Marzo V.
       The hypothalamic levels of the endocannabinoid, anandamide, 
       peak immediately before the onset of puberty in female rats.
       Life Sci. 2002 Feb 8;70(12):1407-14.
       PMID: 11883716 [PubMed - indexed for MEDLINE]

Klein TW, Newton CA, Friedman H. 2001 
       Cannabinoids and the immune system.
       Pain Res Manag. 2001 Summer;6(2):95-101. Review.
       PMID: 11854771 [PubMed - indexed for MEDLINE]

Campbell FA, Tramθr MR, Carroll D, Reynolds DJM, Moore RA, McQuay HJ. 2001
       Are cannabinoids an effective and safe option in the management of pain? 
       A qualitative systematic review. 
       BMJ 2001; 323: 13-16.
Dawn Lyons-Johnson, ARS Information Staff, Greenbelt MD
       Gary D. Weesner 2001?
       Cannabinoid Receptors Key to Stress Response
       USDA-ARS Livestock Behavior Research Unit, Purdue University,

Mikuriya T. 1988-2002
       Collected Works of Dr. Tod Mikuriya
       Dir. Marijuana Research Nat. Inst. Mental Health


20th Century References:

RC Belue, AC Howlett, TM Westlake, DE Hutchings, 1995 The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats, Neurotoxicology and Teratology, 17:1, 25-30, January-February 1995 GB Stefano, Y Liu, MS Goligorsky, 1996 Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes, J Biol Chem, 271:32, 19238-42, August 1996 JJ James, 1997 Medical Marijuana: Unpublished Federal Study Found THC-Treated Rats Lived Longer, Had Less Cancer, AIDS Treatment News 263, January 1997 NTP Technical Report on the Toxicology and Carcinogenesis Studies of 1-Trans-Delta 9-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344/N Rats and B6C3F1 Mice (Gavages Studies), NTP TR 446, NIH Publication No. 94-3362 of US Dept. of HHS, NTP Central Data Management (919) 541-3419 Gifford et.al, 1999 Large receptor reserve for cannabinoid actions in the central nervous system. J. Pharmacol. Exp. Ther. 288:478-483, 1999. Constantine G. Lyketsos, Elizabeth Garrett, Kung-Yee Liang, and James C. Anthony 1999 Cannabis Use and Cognitive Decline In Persons Under 65 Years Old American Journal Of Epidemiology, v.149, No. 9, pp.794-800, 1999 Romero et.al, 1997 Atypical location of cannabinoid receptors in white matter areas during rat brain development. Synapse 26:317-323 (1997). Felder & Glass, 1998 Cannabinoid receptors and their endogenous agonists. Ann. Rev. Pharmacol. Toxicol. 1998 38:179-200. Glass et.al, 1997 Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in fetal neonatal and adult human brain. Neuroscience, Vol 27, No 2, pp. 299-318. Schmid PC, Paria BC, Krebsbach RJ, Schmid HO, Dey SK, 1997 Changes in anandamide levels in mouse uterus associated with uterine receptivity for embryo implantation. Proc. Natational Academy of Science v. 94 p.4188-4192 1997 Dreher MC, Nugent K,Hudgins R., 1994 Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica: An Ethnographic Study Pediatrics, February 1994, Volume 93, Number 2, pp. 254-260. Nelson PL, 1993 Cannabis Amotivational Syndrome And Personality Trait Absorption: A review and reconceptualization Metacognition: Core Readings, Allyn and Bacon, Boston, 1992 Jarbe TU, Hiltunen AJ, Mathis DA, Hanus L, Bruer A, Mechoulam R. 1993 Discriminative stimulus effects and receptor binding of enantiomeric pairs of cannabinoids in rats and pigeons; a comparison. J. Pharmacol. Exp. Ther. 264: 561-569 1993 Coffey RG, Yamamoto Y, Shella E, Pross S. 1996. Tetrahydrocannabinol inhibition of macrophage nitric oxide production. Biochemical Pharmacology 52:743—751. Derocq JM, Segui M, Marchand J, Le Fur G, Casellas P. 1995. Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS Letters 369:177—182. Glass M, Dragunow M, Faull RLM. 1997. Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 77:299—318. Jones RT, Benowitz NL, Herning RI. 1981. Clinical relevance of cannabis tolerance and dependence. Journal of Clinical Pharmacology 21:143S—152S. Sanudo-Pena MC, Tsou K, Delay ER, Hohmann AG, Force M, Walker JM. 1997. Endogenous cannabinoids as an aversive or counter-rewarding system in the rat. Neuroscience Letters 223:125—128. Smith PB, Compton DR, Welch SP, Razdan RK, Mechoulam R, Martin BR. 1994. The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. J. Pharmacology and Experimental Therapeutics 270:219—227. Sulcova E, Mechoulam R, Fride E. 1998. Biphasic effects of anandamide. Pharmacology, Biochemistry and Behavior 59:347—352. Wirguin I, Mechoulam R, Breuer A, Schezen E, Weidenfeld J, Brenner T. 1994. Suppression of experimental autoimmune encephalomyelitis by cannabinoids. Immunopharma-cology 28:209—214. Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG. 1982. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl) 76:245—250. Gallate JE, Saharov T, Mallet PE, McGregor IS, 1999 Increased motivation for beer in rats following the administration of a cannabinoid CB1 receptor agonist. European J Pharmacol 370:233­240. Mailleux P, Vanderhaeghen JJ 1994 Delta-9-tetrahydrocannabinol regulates substance P and enkephalin mRNAs levels in caudate putamen. European J Pharmacol 267:R1­R3. Sidney et al., 1997 Marijuana Use and Mortality American Journal of Public Health. 87(4):585-90, April 1997

Early 20th & 19th Century References:


LaGuardia, F. Mayor NYC 1944 The LaGuardia Committee Report The Marijuana Problem In The City Of New York New York Academy of Medicine, 1944 Roger Adams PhD, 1938-1942 Marijuana Research 1938-41 Marijuana Bull. NY Acad Med 18,705-9 1942 Ruby Red Marijuana Oil JACS 62,196(1940) Robert Walton, MD, 1937 Therapeutic Application Of Marijuana 1937 Editor Scientific American, 1936 Marijuana Menaces Youth Scientific American March 1936 p.150 British Pharmaceutical Codex 1934 Cannabis: Symptoms, Descriptions, Standards, Actions/Uses, Preparations Parke Davis 1930 CANNABIS, U.S.P. (American Cannabis): Fluid Extract No. 598 Hamilton HC, Lescohier AW, Perkins RA, 1913 The Physiological Activity of Cannabis Sativa Journal of the American Pharmaceutical Association (1913) Whineray E., MPS, 1908 The Herb Dangerous 1908 Foulis J, 1900 Two Cases of Poisoning by Cannabis Indica Edinburgh Medical Journal v. 8, 1900 O'Day JC, 1899-1900 Cannabis Indica Poisoning (Overdose of Piso's Cure for Consumption) The Plexus, 1899-1900 Dixon WE, 1899 The Pharmacology of Cannabis indica. 1899 BMJ 1899; ii: 1354-1357. Wood, Spivey And Easterfield, 1890 Cannabinol J. Amer. Chem Soc. Mikuriya, T. MD Introduction To The Indian Hemp Drug Report Indian Hemp Drug Report,1890 Hungerford MC 1884 An Overdose of Hasheesh Harper's ? James H. MD, 1881 A Consumptive Cured The Globe, Canada Tilden & Co. 1858 Tilden's Cannabis Indica Extracts Tilden & Co. New Lebanon NY 1858 Unknown, 1858 Hasheesh And Hasheesh Eaters Harper's New Monthly Magazine No. XCV. April, 1858. Vol. XVI. Kalant OJ, 1970 Ludlow On Cannabis: A Modern Look At 19th Century Drug Addiction Alcohol & Drug Addiction Research Foundation, Toronto Canada Ludlow FH, 1856 The Hasheesh Eater Putnam's Monthly Magazine 1856 Ludlow FH, 1856 The Apocalypse of Hasheesh Putnam's Monthly Magazine 1856 Taylor, B. 1854 The Vision Of Hasheesh Putnam's Monthly Magazine 1954 The Shaffer Library Historical Research On Drug Policy 1800-1850 Gautier, T, etal The Hashish Club The Herb Pantegruleon Baudelaire, Artificial Paradises: on hashish and wine as means of expanding individuality The Marijuana Papers, ed. D. Solomon (New York: Signet, 1966), p. 166. O'Shaughnessy WB, 1839 On the preparations of the Indian hemp, or gunjah (Cannabis indica); their effects on the animal system in health, and their utility in the treatment of tetanus and other convulsive diseases. Trans. Medical and Physical Society of Bengal 1838-18; 40: 71-102, 421-61.

Unpublished References:

Anon, 1972. Vitamin M, The Fat Soluble Vitamin From Marijuana Anon, 2002. Marijuana And Hemp Extraction Techniques Anon, 2002. Cannabinoid Receptor References, 1980-2002

Cannabis Medical Research Library

Medical Info On Marijuana

LA Cannabis Co-op Medical Info

Medical Marijuana Doctors

Vitamin M